AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice
We examined the effects of adeno-associated virus type 8 (AAV8) vector-mediated muscle-directed systemic gene therapy in MLL/AF4-positive ALL using IL24. In a series of in vitro studies, we examined Continue Reading
Gene Regulation Systems for Gene Therapy Applications in the Central Nervous System
Substantial progress has been made in the development of novel gene therapy strategies for central nervous system (CNS) disorders in recent years. However, unregulated transgene expression is a Continue Reading
Scientists Create First Monkeys with Mixed Genomes
Genetic material from six genomes made babies, researchers report Source: HealthDay Related MedlinePlus Page: Genes and Gene Therapy (Source: MedlinePlus Health Continue Reading
Hemophilia B Gene Therapy Receives Orphan Status in USHemophilia B Gene Therapy Receives Orphan Status in US
A promising gene therapy for hemophilia B has received orphan designation from the US Food and Drug Administration. Orphan Drug Approvals (Source: Medscape Today Headlines)MedWorm Sponsor Message: Continue Reading
Gene therapy may promote growth of hair cells in inner ear
Normal hearing depends on the presence of healthy hair cells in the inner ear. Gene therapy has the potential to slow the loss of hair cells and promote the growth of hair cells that have already Continue Reading
Gene Therapy – technologies, Markets and Companies
NEW YORK , Dec. 29, 2011 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue: Gene Therapy - technologies, markets and companies Continue Reading
microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2
In this study, miR-365 expression was found to be downregulated in human colon cancer tissues as compared with that in matched non-neoplastic mucosa tissues, and its downregulation was correlated Continue Reading
Gene editing: not just for translation anymore
Authors: Moira A McMahon, Meghdad Rahdar & Matthew Porteus Engineered nucleases have advanced the field of gene therapy with the promise of targeted genome modification as a treatment for human Continue Reading
Gene therapy with RNAi targeting UHRF1 driven by tumor-specific promoter inhibits tumor growth and enhances the sensitivity of chemotherapeutic drug in breast cancer in vitro and in vivo
In this study, we explored whether UHRF1 can be a therapeutic target for human breast carcinoma. We successfully constructed the tumor-specific shRNA expression vector driven by survivin promoter Continue Reading
Lentivirus transduction of human osteoclast precursor cells and differentiation into functional osteoclasts
This study represents a step towards considering human gene therapy for bone cancer by demonstrating successful transduction of human OcP for use as cellular delivery vehicles to sites of bone Continue Reading
Spiral Proteins Are Efficient Gene Delivery Agents
Clinical gene therapy may be one step closer, thanks to a new twist on an old class of molecules. A group of University of Illinois researchers, led by professors Jianjun Cheng and Fei Wang, have Continue Reading
2011′s best health news
Although Behind the Headlines often spends time explaining mistaken or misguided news reports, the joy of this service is when there are genuinely exciting medical advances to report. Over the past Continue Reading
Gene Mutation May Be Key to Familial Pancreatic Cancer
Research may lead to a screening option for those who might be at hereditary risk Source: HealthDay Related MedlinePlus Pages: Family History, Genes and Gene Therapy, Pancreatic Cancer (Source: Continue Reading
Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway
Conclusions: Our results show a novel anti-inflammatory role for the PI3K/Akt signaling pathway in microglia. They further suggest that IRF3 gene therapy could facilitate the microglial phenotype Continue Reading
The Top 10 Science Stories of 2011
Inevitably, year-end lists invite plenty of debate and criticism, and Scientific American 's is no exception. Certainly, we could have included the discovery of new worlds beyond our solar Continue Reading
Upon the tightrope in prostate cancer: two acrobats on the same tightrope to cross the finishline.
Authors: Farooqi AA, Fayyaz S, Rashid S Abstract Prostate cancer is a multifactorial, multistep progressive disorder that is undruggable to date because of stumbling blocks in the Continue Reading
Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies
Neural cell transplantation and gene therapy have attracted considerable interest as promising therapeutic alternatives for patients with Parkinson's disease (PD). Preclinical and open-label Continue Reading
Diabetic heart failure
New BHF-funded research finds potential for gene therapy to prevent heart condition (Source: BHF National News)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml Continue Reading
Gene Therapy For Ears
Normal hearing depends on the presence of healthy hair cells in the inner ear. Gene therapy has the potential to slow the loss of hair cells and promote the growth of hair cells that have already Continue Reading
Can nerve growth factor gene therapy prevent diabetic heart disease?
New research by academics in the University of Bristol's School of Clinical Sciences has investigated if nerve growth factor (NGF) gene therapy can prevent diabetic heart failure and small vascular Continue Reading
